Newsletter of the Cincinnati Section
of
The American Chemical Society
|
Volume 36 - Number 1
October 1998 |
|
Editor Ed Burton |
Advertising: Jackie Hoofring
|
|
Liaison: Julia Bedell |
Advertising Stuart Oehrle
|
CINTACS is published nine times a year (September through May) by the Cincinnati Section of the American Chemical Society in cooperation with the Oesper Collection in the History of Chemistry of the University of Cincinnati. All changes of address should be sent to Emel Yakali at Raymond Walters College, 9555 Plainfield Road, Cincinnati, OH 45236; 745-5686 or 745-5767 (FAX).
Every member is urged to send in their e-mail address. The message should
consist of the e-mail address in the "From" area and the full name of the
member in the "Subject" area of the message format. Send this information
via e-mail to: ACS@UCRWCU.RWC.UC.EDU
SUBMISSION DEADLINES
The submission deadline for the next Newsletter (November 1998) is Monday, October 5, 1998..
All materials should be sent to:
Dr. Edward Burton, Procter & Gamble, P. O. Box 538707, Cincinnati,
OH 45253.
Telephone: (513) 627-1494, FAX: (513) 627-1233, E-mail: burton.de@pg.com
Positron Emission Tomography (PET) Studies of Drug Action in the Human Brain
Joanna S. Fowler,
Chemistry Department, Brookhaven National Laboratory
Joanna S. Fowler, Chemistry Department, Brookhaven National Laboratory Positron Emission Tomography (PET) is a medical imaging method which uses radiotracers labeled with short lived positron emitting isotopes to track biochemical transformations as well as the movement of drugs in the living human and animal body. The half lives of the positron emitting isotopes commonly used in PET range from about 1 minute to two hours and they are usually produced on a cyclotron. Some of the commonly used positron emitters are isotopes of the elements of life (for example carbon-11: t1/2: 20.4 minutes and nitrogen-15: t1/2: 10 minutes) and can be incorporated into organic compounds without changing the properties of the parent molecule. Positron emitter labeled radiotracers are produced using rapid synthetic organic chemistry to incorporate simple labeled molecules into more complex labeled organic compounds. The energy emitted from positron decay is detected by a positron emission tomograph which provides images of the regional distribution and kinetics of the radiotracer. PET has emerged as an important scientific tool in the clinical neurosciences where it has been used to address problems in psychiatry, neurology and in the mechanisms of action of therapeutic drugs and drugs of abuse. However, it is advances in rapid synthetic chemistry which have played a key role in these investigations and which will continue to be responsible for advancing knowledge of basic biochemical processes which occur in the living human body and changes which occur in disease. This presentation will focus on studies of psychostimulant drugs.
About The Speaker
Joanna S. Fowler received her B.A. in chemistry from the University of South Florida, Tampa in 1964 and her Ph.D. from the University of Colorado in 1967. After post-doctoral research in organometallic chemistry at the University of East Anglia, England she became a post-doctoral fellow in organic synthesis at Brookhaven National Laboratory. Dr. Fowler is now a senior chemist in the chemistry department at BNL and director of the positron emission tomography (PET) program. Her research includes the synthesis and mechanistic studies of radiolabeled positron-emitting organic molecules and application of these molecules to in vivo studies of neurotransmitter activity, neurodegeneration, and drug metabolism.
Dr. Fowler has received a number of awards including the Jacob Javits
Investigator Award in Neurosciences in 1986 and 1993, the American Chemical
Society Northeastern Section's Esselen Award for Chemistry in the Public
Interest, the Brookhaven National Laboratory R&D Award and, most recently,
the Francis P. Garvan-John M. Olin Medal from the American Chemical Society.
She has six patents based upon her work and has published over 250 papers.
Welcome to another yearís activities of the Cincinnati Section of the American Chemical Society. This summer our Section cosponsored a very successful International Conference on Phosphorous Chemistry which set a record for attendance with over 500 participants from 44 countries. On the opening day of the conference we were honored to have former ACS President Helen Free provide a welcoming address to the conferees. Congratulations go to Hal Ebetino for chairing the conference and providing a great kickoff to the International Chemistry Celebration.
Our featured speakers at the monthly meetings this year will provide a variety of interesting topics from archaeology, to brain biochemistry, to applications of bioengineering in the manufacturing of drugs. As in the past, the discussion groups each month will provide additional variety to the meetings. Please note the dates and locations of the monthly meetings listed in this issue of Cintacs and attend as many of the talks and discussion groups as possible.
In addition to the monthly meetings this year will also begin the International Chemistry Celebration (IChC) sponsored by the National ACS. The mission of this celebration is to enhance public appreciation of chemistry and its contributions to everyday life. The Global Salute to Polymers, as part of IChC, will recognize the importance these molecules have in society. More information about IChC can be found at the web site www.chemcenter.org.
A list of the elected officers of the section is included in this issue of Cintacs. Next monthís isssue will have a list of the committee chairs. Both of these will also be available on the Section Web Page (www.che.uc.edu/acs/cinacs.html) along with other activities of the section. Please contact me or any of these individuals to volunteer or offer suggestions.
Sincerely,
Jim Knittel, Chair
College of Pharmacy - University of Cincinnati
james.knittel@uc.edu
October Monthly Meeting
Wednesday, October 7
Vernon Manor
Featured Speaker
Joanna S. Fowler,
Chemistry Department, Brookhaven National Laboratory
PROGRAM
5:30 - 6:15 | Discussion Groups |
Organic: | Edward E. Fenlon, Xavier University, "Silatrane-Nucleosides as Transition State Analogues for Phosphoryl Transfer Reactions" |
Computational: | Anping Liu, University of Cincinnati, "Simulations of Phase Equilibria of Ternary Mixtures and Polyelectrolytes by Gibbs Ensemble and MCBMC" |
6:15 - 6:45 | Social Hour (Cash Bar) |
6:45 - 8:00 | Dinner in the Oak Room (cost $22) |
Choice of: Roast Top Sirloin or Chicken Kiev. | |
All dinners include: mixed green salad, green beans with shallots, potatoes au gratin, New York cheesecake with berry sauce, iced tea and coffee. | |
8:00 |
Brookhaven National Laboratories Positron Emission Tomography (PET) Studies of Drug Action in theHuman Brain |
Dinner reservations: | Call the section answering line at 558-1224 or email cintacs@uc.edu. Include your name with correct spelling, affiliation, and meun choice. Reservations must be received by Friday, October 2. If you have any difficulties, please call Donna Taylor at 558-0979. As a reminder, if you decide you must miss a meeting after you have made reservations, please call to cancel. If not, the section will have to charge you for the dinner because it will be charged for the dinner. |
Directions: | From all directions follow Reading road to just north of William Howard Taft Rd. Take a left onto Oak Street. The Vernon Manor will be on your right, before you reach Burnet Ave. There is complimentary parking in the Hotel's fenced, secured lot. |
To reach the intersection of Reading and Oak:
From the south: | Take I-471 north to I-71 north and take the Liberty Street exit, just over the I-471 bridge. Turn right off the exit. At the next intersection, take Reading Rd. north. Follow Reading past William Howard Taft Rd and continue as above. |
From the north: | Take I-71 south to the Taft Rd. exit. Turn right onto Reading Rd. and follow above directions. |
From downtown: | Take Columbia Parkway east, turn left onto William Howard Taft Rd. Turn right onto Reading Rd. and follow directions above. |
Cincinnati Chemist of the Year
The Section Awards Committee requests nominations for the 1999 Cincinnati Chemist of the Year. This award, given annually since 1950, recognizes professional accomplishments of a member. The 1999 Chemist of the Year will be the featured speaker at the February meeting.
Deadline for nominations is November 18, 1998.
Cincinnati Research Assistant/Technician of the Year
The Section Awards Committee requests nominations for the 1999 Cincinnati Research Assistant/Chemical Technician of the Year. This award, given annually, recognizes job skills, safety, teamwork, leadership, publications and presentations, reliability, communications skills, and additional professional and community activities. A Chemical Technician/Research Assistant is defined as a person whose training includes successful completion of a two year post-high school chemistry curriculum or equivalent work in a Baccalaureate program, or equivalent knowledge gained by experience.
The 1999 award will be presented at the February meeting. The winner will be the section's candidate for the National award.
Deadline for nominations is December 18, 1998.
Nomination forms for each award may be requested from, and returned to:
Henry R. Greeb
Awards Committee Chair
e-Mail: 72277.706@compuserve.com
November 1-7, 1998 marks the 11th anniversary of National Chemistry Week (NCW), and the local section plans on celebrating by continuing our library and museum demonstrations. Last year we had demonstrations in over 25 libraries, and the museum center. This year we are starting NCW early with the first demonstrations scheduled for October 27th.
We are looking for newcomers as well as seasoned demonstrators. The demonstrations are easy and fun. Janice Kagermeier, program coordinator of the Hamilton County public libraries, has said that NCW demonstrations are the most popular children's activity the libraries do each year.
Volunteers can get more information on times and locations of the demonstrations
by calling Ed and Stephanie Fenlon, 513-745-3361 or 606-331-3564 or email:
fenlon@admin.xu.edu or on the section's website: http://www.che.uc.edu/acs/ncw/ncw_cin.html.
We plan to have a demonstrator workshop in early October.
OFFICE | NAME/ADDRESS | PHONE NUMBERS |
Chair | James J. Knittel
University of Cincinnati College of Pharmacy 3223 Eden Avenue Cincinnati, OH 45267-0004 |
Work: (513) 558-0733
Fax:(513)558-0978 e-Mail:James.Knittel@uc.edu |
1st Vice Chair
& Chair-Elect |
Frank H. (Hal) Ebetino
Procter & Gamble P O Box 8006 Mason, OH 45040-8006 |
Work: (513) 622-3630
Fax: (513) 622-1195 E-Mail: ebetino.fh@pg.com |
2nd Vice Chair | Susan Ross
Department of Chemistry University of Cincinnati Cincinnati, OH 45221-0172 |
Work: (513) 556-9207
Fax: (513) 556-9239 Email: rossu@email.uc.edu |
Secretary | Donna Hindman Glaser
1675 Rudyard Lane Cincinnati, OH 45230 |
Home: (513) 232-8223 |
Treasurer | Hank Greeb
Hg Consulting, Inc. 6580 Dry Ridge Rd. Cincinnati, OH 45252-1750 |
Work: (513) 385-8363
Fax: (513) 385-8888 Email: 72277.706@compuserve.com |
Trustee
(until 6/2001) |
William R. Oliver
Department of Chemistry Northern Kentucky University Highland Heights, KY 41099-1905 |
Work: (606) 572-5409
Fax: (606) 572-5162 Email: oliver@nku.edu |
Trustee
(until 6/2000) |
Karlyn A. Schnapp
Department of Chemistry Northern Kentucky University Highland Heights, KY 41099-1905 |
Work: (606) 572-6681
Fax: (606) 572-5162 Email: schnapp@nku.edu |
Trustee
(until 6/99) |
Deanna Ashing
Designeers MidWest 4766 Glendale-Milford Rd. Cincinnati, OH 45242 |
Work: (513) 793-6670
Fax: (513) 793-3616 Email: ashing@designeers.com |
Councilor
(until 12/2001) |
Bruce Ault
Department of Chemistry University of Cincinnati Cincinnati, OH 45221-0172 |
Work: (513) 556-9238
Fax: (513) 556-9239 Email: bruce.ault@uc.edu |
Councilor
(until 12/2001) |
Kathy Gibbony
Procter & Gamble Pharmaceuticals P.O. Box 8006 Mason, OH 45040-8006 |
Work: (513) 622-2289
Fax: (513) 622-1433 Email: gibboney.k@pg.com |
Councilor
(until 12/2000) |
Roger Parker
Nobilent, Inc. 10999 Reed Hartman Hwy. Cincinnati, OH 45242 |
Work: (513) 793-9260
Fax: (513) 793-9701 Email: rogparker@aol.com |
Councilor
(until 12/1999) |
Ted Logan
8880 Livingston Rd Cincinnati, OH 45251-5821 |
Home: (513) 385-8856
Fax: (513) 385-8856 Email: tjlogancin@aol.com |
Alternate Councilor
(1/99-12/2001) |
Jim Hershberger
Department of Chemistry Miami University Oxford, OH 45056 |
Work: (513) 529-2441
Fax: (513) 529-5715 Email: hershbjw@miami.acs.muohio.edu |
Alternate Councilor
(1/99-12/2001) |
Dan McLoughlin
Department of Chemistry Xavier University Cincinnati, OH 45207 |
Work: (513) 745-3352
Fax: (513) 745-1954 Email: mcloughlin@xavier.xu.edu |
Alternate Councilor
(1/99-12/2001) |
Tom Ridgway
Department of Chemistry University of Cincinnati Cincinnati, OH 45221-0172 |
Work: (513) 556-9246
Fax: (513) 556-9239 Email: thomas.ridgway@uc.edu |
Alternate Councilor
(until-12/2000) |
Ray D'Alonzo
Procter & Gamble 11450 Grooms Road Cincinnati, OH 45242 |
Work: (513) 626-1977
Fax: (513) 626-5145 Email: dalonzo.rp@pg.com |
Alternate Councilor
(until 12/1999) |
Edlyn Simmons
Hoechst Marion Roussel, Inc. 2110 E. Galbraith Road Cincinnati, OH 45215 |
Work: (513) 948-7829
Fax: (513) 948-7961 Email: edlynsimmons@hmri.com |
Auditor
(until 6/2001) |
John Shelley
Procter & Gamble Miami Valley Laboratories P.O. Box 538707 Cincinnati, OH 45253-8707 |
Work: (513) 627-0078
Fax: (513) 627-1233 Email: shelley.jc@pg.com |
Auditor
(until 6/2000) |
Diana McGill
Department of Chemistry Northern Kentucky University Highland Heights, KY 41099-1905 |
Work: (606) 572-6520
Fax: (606) 572-5162 Email: mcgill@nku.edu |
Auditor
(until 6/1999) |
Joe Cantrell
Department of Chemistry Miami University Oxford, OH 45056 |
Work: (513) 529-2834
Fax: (513) 529-3841 |
Page updated 1 October 1998. Comments and suggestions to cinacs@www.che.uc.edu